4 ms·

I think it is important to note that a 10% drop (if mostly fat) can bring significant quality of life improvements for people who are experiencing issues relate

by zikzak 6y ago

I think it is important to note that a 10% drop (if mostly fat) can bring significant quality of life improvements for people who are experiencing issues related to obesity. Imagine you walk around with a 30 lbs bag of flour on your back all the time. Then, all of a sudden, you are able to put that bag down. The faster you lose weight (this is all anecdotal) the more it is like putting that bag down all at once. Now, can they keep the weight of after losing it? Because I can gain those 30 lbs back very, very quickly.

engineer_22 6y ago
If the drug can be administered long term, perhaps there is hope they will keep the weight off.
- Cthulhu_ 6y ago
  If it is the same as the glucagon hormone mentioned by the grandparent comment, it SHOULD be 'natural' and have no side effects. But just look at reproductive hormone treatments (the pill) to see how things like this can go wrong (serious mental side effects; my sister struggled with seasonal depression for half her life, turns out it was just the pill. My girlfriend developed suicidal ideation from the Mirena coil. They stopped a research in male anticonception medication because of the mood swings).
pratik661 6y ago
I was overweight when the pandemic started (24% bf). I lost 10% of my body weight in a few months. It’s insane how much your athletic ability jumps just from that. I used to work out intensely before and would make marginal improvements in stamina/speed/etc.
AnIdiotOnTheNet 6y ago
In my experience it is losing the initial weight that is the easy part and keeping it off long term that's hard. However the mechanism the drug uses sounds promising that regard (assuming your body doesn't adapt to it), although it would mean adding another lifetime drug to my list.
P_I_Staker 6y ago
Yeah, I have sleep apnea and GERD, likely related to obesity (I drank beer and coffee constantly for my entire adult life too though; coffee so I could work, beer after to relax)... but I'm wondering how much is related to obesity. I can feel the fat pushing and creating pressure points, which contributes to both conditions. The crazy thing, is I'm not like super fat or anything. 6'2" 245lbs was my max, and I'm at 235lbs now... I felt perfectly fine at 225 when I worked out. Seems like such a small difference, but I've gotten virtually no exercise with covid, so it's not a fair comparison. That's enough for obesity, but the crazy thing is it's not considered fat at all in the USA, if you're a guy. You just "aren't in your early 20s anymore", or have a "dad bod", or you're a loveable jolly rascal that loves life (eg. Chris Pratt in P&R). We act like it's practically inevitable and not a horrific medical condition that's causing me to be eaten from the inside out by my own acid. I know some of this is just luck, but I wonder what truly fat people have to deal with. I couldn't imagine my reflux being better if I was say 275-300+.
- sn9 6y ago
  Parts 6 and 7 of this Youtube series on the risks of obesity are on sleep apnea and GERD: https://www.youtube.com/watch?v=MGnVgbUHtKI&list=PLyqKj7LwU2Rt-rwTADidq3JDJjv9_W2aV&index=13 https://www.youtube.com/watch?v=MGnVgbUHtKI&list=PLyqKj7LwU2...

by zikzak 6y ago

engineer_22 6y ago

If the drug can be administered long term, perhaps there is hope they will keep the weight off.

Cthulhu_ 6y ago
If it is the same as the glucagon hormone mentioned by the grandparent comment, it SHOULD be 'natural' and have no side effects. But just look at reproductive hormone treatments (the pill) to see how things like this can go wrong (serious mental side effects; my sister struggled with seasonal depression for half her life, turns out it was just the pill. My girlfriend developed suicidal ideation from the Mirena coil. They stopped a research in male anticonception medication because of the mood swings).

pratik661 6y ago

I was overweight when the pandemic started (24% bf). I lost 10% of my body weight in a few months. It’s insane how much your athletic ability jumps just from that. I used to work out intensely before and would make marginal improvements in stamina/speed/etc.

AnIdiotOnTheNet 6y ago

In my experience it is losing the initial weight that is the easy part and keeping it off long term that's hard. However the mechanism the drug uses sounds promising that regard (assuming your body doesn't adapt to it), although it would mean adding another lifetime drug to my list.

P_I_Staker 6y ago

Yeah, I have sleep apnea and GERD, likely related to obesity (I drank beer and coffee constantly for my entire adult life too though; coffee so I could work, beer after to relax)... but I'm wondering how much is related to obesity. I can feel the fat pushing and creating pressure points, which contributes to both conditions. The crazy thing, is I'm not like super fat or anything. 6'2" 245lbs was my max, and I'm at 235lbs now... I felt perfectly fine at 225 when I worked out. Seems like such a small difference, but I've gotten virtually no exercise with covid, so it's not a fair comparison. That's enough for obesity, but the crazy thing is it's not considered fat at all in the USA, if you're a guy. You just "aren't in your early 20s anymore", or have a "dad bod", or you're a loveable jolly rascal that loves life (eg. Chris Pratt in P&R). We act like it's practically inevitable and not a horrific medical condition that's causing me to be eaten from the inside out by my own acid. I know some of this is just luck, but I wonder what truly fat people have to deal with. I couldn't imagine my reflux being better if I was say 275-300+.

sn9 6y ago
Parts 6 and 7 of this Youtube series on the risks of obesity are on sleep apnea and GERD: https://www.youtube.com/watch?v=MGnVgbUHtKI&list=PLyqKj7LwU2Rt-rwTADidq3JDJjv9_W2aV&index=13 https://www.youtube.com/watch?v=MGnVgbUHtKI&list=PLyqKj7LwU2...