Could it be that the drugs are to a degree just helping the person escape some level of stress, then they build a tolerance to it and those stress inducing thou

Could it be that the drugs are to a degree just helping the person escape some level of stress, then they build a tolerance to it and those stress inducing thoughts or hormone levels return? Has anyone studied the persons hormone levels Serotonin, Cortisol, Epinephrine, Dopamine, Prolactin, etc... before, throughout and after the tests?