Another fine article by Derek Lowe: > The adenoviruses have long been used as tools in molecular biology, since they have plenty of room to carry a modified DN

Another fine article by Derek Lowe: > The adenoviruses have long been used as tools in molecular biology, since they have plenty of room to carry a modified DNA payload, show no tendencies to integrate DNA into the host genomes, and can infect both dividing and nondividing cells. But as those figures just cited show, a downside of using them as human therapies is that many people may well already have antibodies to your viral vector tool right at the start, which will surely knock down its effectiveness. For this reason, there has been a long-running search for rare and unusual Ad forms to use as platforms, which explains why you see J&J and Gamaleya using Ad26, Oxford/AZ using a virus from chimpanzees that’s not in the human population, ReiThera using a gorilla adenovirus, etc. And it’s also why people wonder about CanSino’s efficacy in general, since they stayed with Ad5.