4 ms·
Besides the obvious safety concerns, I also have some serious doubts about the efficacy. It's quite well known that the glycosylation of the spike protein ("dec
by folli 6y ago
Besides the obvious safety concerns, I also have some serious doubts about the efficacy. It's quite well known that the glycosylation of the spike protein ("decorating" sugar structures) contributes significantly to immunerecognition (see e.g. https://www.nature.com/articles/s41598-020-71748-7 https://www.nature.com/articles/s41598-020-71748-7).
By chemically synthesizing naked (non-glycosylated) protein fragments, you likely end up with the wrong antigen.
- flobosg 6y agoThat’s a good point. In this case the spike-derived peptides have no known N-linked glycosylation sites[1] and the paper you mentioned showed that at least some of those epitopes are accessible even when taking glycans into consideration. [1]: https://science.sciencemag.org/content/369/6501/330 https://science.sciencemag.org/content/369/6501/330