4 ms·

Curious whether short peptides are sufficient to generate a formidable immune response. Looking at the paper cited, it's not trivial to detect T-cell immunity

by kneel 6y ago

Curious whether short peptides are sufficient to generate a formidable immune response. Looking at the paper cited, it's not trivial to detect T-cell immunity so I'm not sure a general antibody test would be able to pick up an immune response. It's probably better than doing nothing, but it's not clear whether it's even in the same ballpark as a Pfizer vaccine. edit: I'm not sure about t-cell vs b-cell responses in immunoassays, can anyone with experience point out what is going on with these peptides?

jfjrkrkfjf 6y ago
Not an expert, but I've read that the antigen presenting cells break down the antigen into short peptides too (8-20 amino acids) when creating antibodies. One might however still ask if the body is better at selecting exactly which portions are cut and chosen than however these were selected. Also, if the antigen is small from the start, that might have implications too (like being ignored).
crazydoggers 6y ago
They’re not sufficient without an adjuvant. Peptides by themselves usually aren’t enough to be recognized as pathogenic. If any peptide by itself could kick off an immune response, you’d be getting sick with everything you eat and smell. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4494216/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4494216/
- Kim_Bruning 6y ago
  The protocol white paper uses Chitosan. They do discuss use of Alum and other adjuvants, starting on page 12. ( https://radvac.org/wp-content/uploads/2020/12/White-Paper-SARS-CoV-2-vaccine-ver-3-3-1.pdf https://radvac.org/wp-content/uploads/2020/12/White-Paper-SA... )
tim333 6y ago
I rather doubt snorting some peptides as described will do much. There are some attempts to make actual nasal covid vaccines and I think they use chimpanzee adenovirus vectors. Ie you get a virus that gives chips colds and add some covid bits on. See the Indian one for example https://indianexpress.com/article/explained/explained-understanding-bbv154-bharat-biotechs-single-dose-intranasal-covid-19-vaccine-7160945/ https://indianexpress.com/article/explained/explained-unders... I think they also were talking of trying the AstraZenca one nasally which is also a modified chimp virus.

by kneel 6y ago

jfjrkrkfjf 6y ago

Not an expert, but I've read that the antigen presenting cells break down the antigen into short peptides too (8-20 amino acids) when creating antibodies. One might however still ask if the body is better at selecting exactly which portions are cut and chosen than however these were selected. Also, if the antigen is small from the start, that might have implications too (like being ignored).

crazydoggers 6y ago

They’re not sufficient without an adjuvant. Peptides by themselves usually aren’t enough to be recognized as pathogenic. If any peptide by itself could kick off an immune response, you’d be getting sick with everything you eat and smell. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4494216/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4494216/

Kim_Bruning 6y ago
The protocol white paper uses Chitosan. They do discuss use of Alum and other adjuvants, starting on page 12. ( https://radvac.org/wp-content/uploads/2020/12/White-Paper-SARS-CoV-2-vaccine-ver-3-3-1.pdf https://radvac.org/wp-content/uploads/2020/12/White-Paper-SA... )

tim333 6y ago

I rather doubt snorting some peptides as described will do much. There are some attempts to make actual nasal covid vaccines and I think they use chimpanzee adenovirus vectors. Ie you get a virus that gives chips colds and add some covid bits on. See the Indian one for example https://indianexpress.com/article/explained/explained-understanding-bbv154-bharat-biotechs-single-dose-intranasal-covid-19-vaccine-7160945/ https://indianexpress.com/article/explained/explained-unders... I think they also were talking of trying the AstraZenca one nasally which is also a modified chimp virus.