5 ms·

Do these "modern pharmaceutical manufacturing standards" actually buy us extra safety? Yes, but we pay a price: * Evaluations take a really long time. So it

by Sukotto 15y ago

Do these "modern pharmaceutical manufacturing standards" actually buy us extra safety? Yes, but we pay a price: * Evaluations take a really long time. So it's hard to get the drugs into the hands of people. * Development is now extremely expensive. That forces just about everyone except the largest drug mega-corporations out of the market. * Drugs that would be a net benefit to the world sometimes never make it through the entire process because the ROI isn't good enough, or the associated side effects are deemed too harsh. (We would likely not have aspirin today if it hadn't been developed prior to the modern way of drug development... it has too many high-risk side effects) -- On the plus side: * The drugs you do get are generally far safer and better understood than they otherwise would be * You can feel safe that each batch of the drug was made the same way, using the same process, and ends up having the same strength/effectiveness as every other batch of the same drug... even when made by a different company. (We take that for granted now... but it's actually a really big deal if you look at medication from a historical perspective.) * We have far fewer snake-oil salesmen ripping people off for cures that are, at best, useless and at worst, cause the condition to get worse, or cause birth defects, or some other harm. If we do find the drug doing harm, it gets pulled off the market

jonprins 15y ago
"We also have far fewer snake-oil salesmen ripping people off for cures" Yet we still have chiropractors and homeopathy.
- cwp 15y ago
  Two weeks ago I went to see a chiropractor. I was in so much pain I could barely walk, and my lower back wouldn't flex enough for me to stand up straight. She thought I probably had a pulled muscle. She stretched my legs and hips, twisted my spine a bit and showed me some stretches that I could do at home. I left feeling a bit sore, but otherwise fine. It took 20 minutes and cost me $60. It might not be medicine, but it's not snake-oil either.
- sorbus 15y ago
  Sadly, they get around all the regulation by not making specific medical claims. If they did, then regulation would come down on them like a ton of bricks (as it did to producers of Cherries at one point). It's the difference between saying "Product X will cure Y" (illegal unless it's gone through all the testing) and "Product X may promote health" (which is entirely legal). It doesn't make much sense.
- ghshephard 15y ago
  Hold on - Chiropractors are in the same class as homeopathy? I thought Chiropractors (which, admittedly, I've never been to, but have heard many good things about - particularly when people need to get their back "adjusted") were in the same class as Acupuncturists - kind of easternish philosophy, but effective within their domain. Not so much focussed on increasing health, as enhancing comfort (or reducing pain) without drugs. Not the case?
  - Xurinos 15y ago
    I would like to know the real answer on this, too. I have read from people who claim to have been on the industry's inside (went to school for it, etc). The claim is that there are a bunch of logical steps based on false premises/beliefs and that some of the work results in mid- to long-term damage to the body in exchange for short-term relief. Edit: http://www.chirobase.org/05RB/CPSQ/02.html http://www.chirobase.org/05RB/CPSQ/02.html -- More information that looks like something I have read. Edit2: http://www.chirobase.org/01General/controversy.html http://www.chirobase.org/01General/controversy.html -- "NACM members publicly renounce the subluxation theory and other forms of chiropractic pseudomedicine." Interesting stuff. What I read: There is a portion of "chiropractic medicine" that is snake oil; how do I identify what is real? Are NACM members better informed?
  - bmohlenhoff 15y ago
    I've been to a chiropractor before and it really does work, at least for the problem I was experiencing (which was some sort of simple alignment problem.) The guy basically just pushed on my spinal column in different directions and I could clearly feel things moving back into place. I definitely would not lump them in with the quackery that is homeopathy, as long as you stay within the bounds of "pushing bones into alignment" and stay away from things like "improve the chi flow throughout your chakra nodes" or some such nonsense.
    - jonprins 15y ago
      Until you realize that your bones were 'out of alignment' because you have weak core muscles that you should build up instead. In fact, 'pushing spinal column bones into alignment' without any x-rays or further inspection sounds pretty dangerous to me. What if the chiropractor pushes it too far and strains something, causing me to return for another adjustment? Everyone I know who has tried a chiropractor ends up going back over and over again, like an addiction. Meanwhile, I had some back pain and started doing pilates and it evaporated, because now my core can actually hold my backbone up. /plural of anecdote is not data
Symmetry 15y ago
Like almost everything, testing suffers from diminishing returns. The difference between no testing and delta testing is often huge, but the difference between a lot and a lot plus delta is often pretty small. But each delta of testing you add costs the same amount in terms of the prices you listed. The optimal thing to do would be to keep adding more testing until the benefits of the latest delta drop to equal their costs. However, all the economic research on this topic that I've read suggests that while we need some testing we're way over the optimal point. Its the same sort of research that lets you publish papers on how the optimal copyright length is 14 years. The same sort of ratchet effects are involved in both places too. The only people who care passionately about copyright lengths are those who have copyrights that are about to expire. The people who could have benefited from a work going out of copyright are often only dimly aware of it. Likewise when the FDA approves a drug that causes problems its obvious and there are a lot of people complaining, but when they don't approve a drug that could have helped someone - or when drug developers are scared off - people aren't as aware of it.

by Sukotto 15y ago

jonprins 15y ago

"We also have far fewer snake-oil salesmen ripping people off for cures" Yet we still have chiropractors and homeopathy.

cwp 15y ago
Two weeks ago I went to see a chiropractor. I was in so much pain I could barely walk, and my lower back wouldn't flex enough for me to stand up straight. She thought I probably had a pulled muscle. She stretched my legs and hips, twisted my spine a bit and showed me some stretches that I could do at home. I left feeling a bit sore, but otherwise fine. It took 20 minutes and cost me $60. It might not be medicine, but it's not snake-oil either.
sorbus 15y ago
Sadly, they get around all the regulation by not making specific medical claims. If they did, then regulation would come down on them like a ton of bricks (as it did to producers of Cherries at one point). It's the difference between saying "Product X will cure Y" (illegal unless it's gone through all the testing) and "Product X may promote health" (which is entirely legal). It doesn't make much sense.
ghshephard 15y ago
Hold on - Chiropractors are in the same class as homeopathy? I thought Chiropractors (which, admittedly, I've never been to, but have heard many good things about - particularly when people need to get their back "adjusted") were in the same class as Acupuncturists - kind of easternish philosophy, but effective within their domain. Not so much focussed on increasing health, as enhancing comfort (or reducing pain) without drugs. Not the case?
- Xurinos 15y ago
  I would like to know the real answer on this, too. I have read from people who claim to have been on the industry's inside (went to school for it, etc). The claim is that there are a bunch of logical steps based on false premises/beliefs and that some of the work results in mid- to long-term damage to the body in exchange for short-term relief. Edit: http://www.chirobase.org/05RB/CPSQ/02.html http://www.chirobase.org/05RB/CPSQ/02.html -- More information that looks like something I have read. Edit2: http://www.chirobase.org/01General/controversy.html http://www.chirobase.org/01General/controversy.html -- "NACM members publicly renounce the subluxation theory and other forms of chiropractic pseudomedicine." Interesting stuff. What I read: There is a portion of "chiropractic medicine" that is snake oil; how do I identify what is real? Are NACM members better informed?
- bmohlenhoff 15y ago
  I've been to a chiropractor before and it really does work, at least for the problem I was experiencing (which was some sort of simple alignment problem.) The guy basically just pushed on my spinal column in different directions and I could clearly feel things moving back into place. I definitely would not lump them in with the quackery that is homeopathy, as long as you stay within the bounds of "pushing bones into alignment" and stay away from things like "improve the chi flow throughout your chakra nodes" or some such nonsense.
  - jonprins 15y ago
    Until you realize that your bones were 'out of alignment' because you have weak core muscles that you should build up instead. In fact, 'pushing spinal column bones into alignment' without any x-rays or further inspection sounds pretty dangerous to me. What if the chiropractor pushes it too far and strains something, causing me to return for another adjustment? Everyone I know who has tried a chiropractor ends up going back over and over again, like an addiction. Meanwhile, I had some back pain and started doing pilates and it evaporated, because now my core can actually hold my backbone up. /plural of anecdote is not data

Symmetry 15y ago

Like almost everything, testing suffers from diminishing returns. The difference between no testing and delta testing is often huge, but the difference between a lot and a lot plus delta is often pretty small. But each delta of testing you add costs the same amount in terms of the prices you listed. The optimal thing to do would be to keep adding more testing until the benefits of the latest delta drop to equal their costs. However, all the economic research on this topic that I've read suggests that while we need some testing we're way over the optimal point. Its the same sort of research that lets you publish papers on how the optimal copyright length is 14 years. The same sort of ratchet effects are involved in both places too. The only people who care passionately about copyright lengths are those who have copyrights that are about to expire. The people who could have benefited from a work going out of copyright are often only dimly aware of it. Likewise when the FDA approves a drug that causes problems its obvious and there are a lot of people complaining, but when they don't approve a drug that could have helped someone - or when drug developers are scared off - people aren't as aware of it.