3 ms·
This is very innacurate. We have the following data: -Moderna data between the 1st and 2nd dose at 28 days -Pfizer data between the 1st and 2nd dose at 21 days
by mchusma 6y ago
This is very innacurate. We have the following data:
-Moderna data between the 1st and 2nd dose at 28 days
-Pfizer data between the 1st and 2nd dose at 21 days
-Aztrazeneca data between 1st & second dose at various dosing schedules
-J&J data
-Novavax data
-Data from Isreal real world deployments of the vaccine
-Data from UK First Dose First effort
-Our Bayseian priors - <30 day boosters are almost never tried in the real world because larger time gaps typically illicit better protective responses.
You can read the FDA briefings for Moderna & Pfizer which review the 1 dose data, its very readable.
The empirical data is overwhelming from many sources and the data matches our current disease models. All signs suggest overwhelmingly that: (1) 1 dose appears to be 100% effective at preventing death in all candidates >14 days after the 1st dose. (2) The marginal benefit of the second dose is real but comparatively much smaller. (3) The delaying the second dose appears to confer additional immunity.
Focusing on 1st doses is by far the best decision.