Please note, i am not claiming certainty and there are studies that point against the hygiene hypothesis. I am just stating that there is a growing body of evid

Please note, i am not claiming certainty and there are studies that point against the hygiene hypothesis. I am just stating that there is a growing body of evidence for the links between household cleanliness (and use of certain household cleaning products) and microbiome disruption. And links between microbiome disruption and prevalence of disease. For the American obsession with cleanliness in the 1950's, two things: autoimmune is hard to diagnose and many suffered in silence for decades AND cleaning up a lot is distinctly different from the proliferation of chemically based cleaning products many of which containing anti bacterial ingredients. Many look at the trend of autoimmune rise starting in the 70's and 80's. Let's say you're right about the 50's cleanliness, the children born then might not have been diagnosed, the cleanliness trend started then but built up to have large effect over 20-30 years, and/or it took time for chemicals to proliferate into household daily cleaning. I am NOT a tin foil hat wearer. I have an autoimmune disease and have researched the topic a lot. I am claiming NO certainty, just that the immune system is woefully insufficiently understood and that links with growing evidence should NOT be ignored. https://onlinelibrary.wiley.com/doi/abs/10.1111/apm.12023 https://onlinelibrary.wiley.com/doi/abs/10.1111/apm.12023 https://oem.bmj.com/content/74/9/684.abstract https://oem.bmj.com/content/74/9/684.abstract https://www.atsjournals.org/doi/full/10.1164/rccm.200612-1793OC https://www.atsjournals.org/doi/full/10.1164/rccm.200612-179... https://www.embopress.org/doi/full/10.15252/emmm.201707882 https://www.embopress.org/doi/full/10.15252/emmm.201707882 https://www.cmaj.ca/content/190/37/E1097?_ga=2.113661191.1490908815.1539388800-1636001196.1539388800 https://www.cmaj.ca/content/190/37/E1097?_ga=2.113661191.149... https://www.sciencedirect.com/science/article/abs/pii/S0171298507000332 https://www.sciencedirect.com/science/article/abs/pii/S01712... https://www.sciencedirect.com/science/article/abs/pii/S0171298507000393 https://www.sciencedirect.com/science/article/abs/pii/S01712...