Always, if used correctly. i.e. = in other words, e.g. = for example. Surely, as a native English speaker, you can see the huge difference? One is definitive, t

Always, if used correctly. i.e. = in other words, e.g. = for example. Surely, as a native English speaker, you can see the huge difference? One is definitive, the other is presenting one or more examples.