For me personally, it is only really noticeable when I shift my eyes from one of the middle 4K screens to the 1080p screen. I am a little picky about fonts and

For me personally, it is only really noticeable when I shift my eyes from one of the middle 4K screens to the 1080p screen. I am a little picky about fonts and their display though. The higher resolution the screen, the better. I have my Emacs configuration using a bunch of different fonts and sizes/weights/etc for my Org-mode, Terraform, TypeScript, and other editing. For example, when a todo item is put into "in progress" the heading is slightly larger and bolder, and when that item is complete, marking it "done" changes the text to italic, extra-light, and grey to reduce its visibility. Time spent messing around with fonts is definitely an expression of ADHD and active procrastination, but I do get a pleasing effect from it! :)