> A constellation of physiological and social factors drives those grim numbers. The biology of obesity includes impaired immunity, chronic inflammation, and bl

> A constellation of physiological and social factors drives those grim numbers. The biology of obesity includes impaired immunity, chronic inflammation, and blood that’s prone to clot, all of which can worsen COVID-19. And because obesity is so stigmatized, people with obesity may avoid medical care. We seem to ignore tissue tropism [1] when it comes to COVID-19. The disease starts in the upper respiratory tract, progresses to the lower respiratory tract (viral pneumonia) for a subset of infections, and severe lung infections can spread to adjacent blood vessels (vasculitis). A similar progression can start in the gastrointestinal system in a different subset, including kids. The solution is to stop the infection or slow its progression. Vaccinations are critical. A daily paper strip antigen test regiment with early in-home intravenous monoclonal antibody therapy for high risk groups, including the elderly and/or obese, could have saved many lives and still can. [1] https://en.m.wikipedia.org/wiki/Tissue_tropism https://en.m.wikipedia.org/wiki/Tissue_tropism