3 ms·
Paper's DOI: https://doi.org/10.1371/journal.ppat.1009212 https://doi.org/10.1371/journal.ppat.1009212 Wayback URL: https://web.archive.org/web/20210122215919
by 8bitsrule 6y ago
Paper's DOI: https://doi.org/10.1371/journal.ppat.1009212 https://doi.org/10.1371/journal.ppat.1009212
Wayback URL: https://web.archive.org/web/20210122215919/https://journals.plos.org/plospathogens/article?id=10.1371%2Fjournal.ppat.1009212 https://web.archive.org/web/20210122215919/https://journals....
Summary conclusion: "Finally, we show that combinations of hydroxychloroquine and a clinically tested TMPRSS2 inhibitor work together to effectively inhibit SARS-CoV-2 entry. Thus TMPRSS2 expression on physiologically relevant SARS-CoV-2 target cells may bypass the antiviral activities of hydroxychloroquine, and explain its lack of in vivo efficacy... "