3 ms·

https://www.wsj.com/articles/hydroxychloroquine-given-early-helped-coronavirus-patients-study-finds-11593729664 https://www.wsj.com/articles/hydroxychloroquine-

https://www.wsj.com/articles/hydroxychloroquine-given-early-helped-coronavirus-patients-study-finds-11593729664 https://www.wsj.com/articles/hydroxychloroquine-given-early-... Not a doctor or well read on the subject but I have seen some studies claiming it does. Have also seen many studies saying there is no benefit too. Seeing such wild contradiction from respectable medical sources makes me wonder if anyone really knows what does what.

lazyeye 6y ago
Its become political. If you are prepared to consider the possibility that hydrochloroquine could be beneficial, it means you are a Trump supporter.
- rualca 6y ago
  > Its become political. Hydroxychloroquine was never anything other than pure political propaganda. It was the promise of a magical politically endorsed silver bullet designed to mitigate the political fallout of having to manage a pandemic with little to no success. Pure believers were not only kept in line because of the empty promises of a solution to their personal problem but also mobilized to persecute any contrasting opinion.
  - lazyeye 6y ago
    As I said...
  - dTal 6y ago
    This is not correct. Chloroquine was first suggested as a possible treatment by Chinese researchers in early February - well before there was even any attempt to manage a pandemic in the west. Those of us who were paying attention at the time were watching it carefully (and in some cases even buying supplies of it in case it proved effective). When Trump jumped on it (trailing a social media storm by several days) we all collectively groaned at the inevitable politicization. You surely didn't think that Trump picked a drug at random? https://thediplomat.com/2020/04/how-wuhan-virologists-pegged-chloroquine-as-a-potential-covid-19-cure/ https://thediplomat.com/2020/04/how-wuhan-virologists-pegged...
- zug_zug 6y ago
  I would upvote you for rightly pointing out that it seems political, which is worth calling out, but I disagree with your sarcastic tone. But largely, yes, somehow, in some people's heads I think people have made an emotion association that endorsement of a drug is somehow a validation of an ex-political-figure. Hopefully that can all be put behind us now. I looked on wikipedia and found "Hydroxychloroquine is being studied to prevent and treat coronavirus disease 2019 (COVID‑19), but all clinical trials conducted during 2020 found it is ineffective and may cause dangerous side effects.[3][4][5][6]" But interestingly, the systematic review it referenced concluded "There is sufficient pre-clinical rationale and evidence regarding the effectiveness of chloroquine for treatment of COVID-19 as well as evidence of safety from long-time use in clinical practice for other indications [3] to justify clinical research on the topic." The rest of the citations were prior to June. I'm not specifically saying it does or doesn't work, I couldn't care less. I do care about citations matching.
rualca 6y ago
> Not a doctor or well read on the subject but I have seen some studies claiming it does. Your source is quite old and only provides baseless speculation about an hypothesis where hydroxychloroquine might play a role in treating covid-19 effectively. If you invest some time searching for the topic you'll find a multitude of studies which failed to find any evidence that hydroxychloroquine has any effect at all. Taken for example, this article. https://www.thelancet.com/journals/lanrhe/article/PIIS2665-9913(20)30390-8/fulltext https://www.thelancet.com/journals/lanrhe/article/PIIS2665-9... This paper might not have been accepted by the Wall Street Journal but in it the author's point out tjat multiple high-quality studies subsequently showed no benefit of hydroxychloroquine use as post-exposure prophylaxis3 or as a COVID-19 treatment. The author's proceed to address the hypothesis that prior long term treatment with hydroxychloroquine by autoimmune disease patients was a factor, and cite a study that "found no significant difference in standardised cumulative COVID-19 mortality associated with hydroxychloroquine use". The author's then state quite unambiguously the following: >These findings are not surprising given the mounting body of literature suggesting no clinical benefit for hydroxychloroquine use against COVID-19. However, this study is important in addressing the potential role, or lack thereof, for hydroxychloroquine as a preventive medication for this novel infectious disease.

lazyeye 6y ago

Its become political. If you are prepared to consider the possibility that hydrochloroquine could be beneficial, it means you are a Trump supporter.

rualca 6y ago
> Its become political. Hydroxychloroquine was never anything other than pure political propaganda. It was the promise of a magical politically endorsed silver bullet designed to mitigate the political fallout of having to manage a pandemic with little to no success. Pure believers were not only kept in line because of the empty promises of a solution to their personal problem but also mobilized to persecute any contrasting opinion.
- lazyeye 6y ago
  As I said...
- dTal 6y ago
  This is not correct. Chloroquine was first suggested as a possible treatment by Chinese researchers in early February - well before there was even any attempt to manage a pandemic in the west. Those of us who were paying attention at the time were watching it carefully (and in some cases even buying supplies of it in case it proved effective). When Trump jumped on it (trailing a social media storm by several days) we all collectively groaned at the inevitable politicization. You surely didn't think that Trump picked a drug at random? https://thediplomat.com/2020/04/how-wuhan-virologists-pegged-chloroquine-as-a-potential-covid-19-cure/ https://thediplomat.com/2020/04/how-wuhan-virologists-pegged...
zug_zug 6y ago
I would upvote you for rightly pointing out that it seems political, which is worth calling out, but I disagree with your sarcastic tone. But largely, yes, somehow, in some people's heads I think people have made an emotion association that endorsement of a drug is somehow a validation of an ex-political-figure. Hopefully that can all be put behind us now. I looked on wikipedia and found "Hydroxychloroquine is being studied to prevent and treat coronavirus disease 2019 (COVID‑19), but all clinical trials conducted during 2020 found it is ineffective and may cause dangerous side effects.[3][4][5][6]" But interestingly, the systematic review it referenced concluded "There is sufficient pre-clinical rationale and evidence regarding the effectiveness of chloroquine for treatment of COVID-19 as well as evidence of safety from long-time use in clinical practice for other indications [3] to justify clinical research on the topic." The rest of the citations were prior to June. I'm not specifically saying it does or doesn't work, I couldn't care less. I do care about citations matching.

rualca 6y ago

> Not a doctor or well read on the subject but I have seen some studies claiming it does. Your source is quite old and only provides baseless speculation about an hypothesis where hydroxychloroquine might play a role in treating covid-19 effectively. If you invest some time searching for the topic you'll find a multitude of studies which failed to find any evidence that hydroxychloroquine has any effect at all. Taken for example, this article. https://www.thelancet.com/journals/lanrhe/article/PIIS2665-9913(20)30390-8/fulltext https://www.thelancet.com/journals/lanrhe/article/PIIS2665-9... This paper might not have been accepted by the Wall Street Journal but in it the author's point out tjat multiple high-quality studies subsequently showed no benefit of hydroxychloroquine use as post-exposure prophylaxis3 or as a COVID-19 treatment. The author's proceed to address the hypothesis that prior long term treatment with hydroxychloroquine by autoimmune disease patients was a factor, and cite a study that "found no significant difference in standardised cumulative COVID-19 mortality associated with hydroxychloroquine use". The author's then state quite unambiguously the following: >These findings are not surprising given the mounting body of literature suggesting no clinical benefit for hydroxychloroquine use against COVID-19. However, this study is important in addressing the potential role, or lack thereof, for hydroxychloroquine as a preventive medication for this novel infectious disease.