Yeah, this seems like someone said: 'If it's a huge effect, we should be able to see it with a relatively weak study.' As it turns out, the weak study turned up

Yeah, this seems like someone said: 'If it's a huge effect, we should be able to see it with a relatively weak study.' As it turns out, the weak study turned up nothing, indicating it's either a weaker effect or the study was pointed at the wrong people in one way or another (eg, northern europeans may have different response from people in india, or there's a smaller subpopulation that it makes a difference for, but they get lost in the bigger study).