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What are some example of papers you've seen that, in your opinion, do a good job of mitigating the effects of horizontal pleiotropy?
by whoisburbansky 6y ago
What are some example of papers you've seen that, in your opinion, do a good job of mitigating the effects of horizontal pleiotropy?
- wxnx 6y agoGood question! A popular motif (and perhaps the most illustrative example) is to restrict the instrument to be genotype variants within a specific gene, and use its protein product (for example, its serum concentration) as the exposure [1]. In this way, horizontal pleiotropy is significantly mitigated. This is sort of a natural extension (on a statistical methodological level, really a simplification) of a popular technique where a drug which has a known protein target is used in a "factorial MR" scheme [2]. Unfortunately, I'm less familiar with the literature here because it's very domain-specific. [1] doi:10.2337/dc18-2444 [2] doi:10.1016/j.jacc.2015.02.020 Edit: removed one of the references because it's a somewhat convoluted example, and on a deeper read, wasn't actually the paper I was thinking of.