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The summary is that NAD+ is limited for cancer cells, so NAD+ depletion could be a promising cancer therapy. On the other hand, a recent paper shows that NAD+
by pazimzadeh 6y ago
The summary is that NAD+ is limited for cancer cells, so NAD+ depletion could be a promising cancer therapy.
On the other hand, a recent paper shows that NAD+ replenishment reverts tumor resistance to immunotherapy, so those therapies shouldn't be combined.
https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30554-4 https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)...