3 ms·
[1] Say replacing the hydrogens in glucose with tritium That's part of the problem. Think you can come up with a synthesis of glucose that replaces the nonlabi
by dnautics 6y ago
[1] Say replacing the hydrogens in glucose with tritium
That's part of the problem. Think you can come up with a synthesis of glucose that replaces the nonlabile hydrogens with tritium, is doable on the days scale, repurifiable for human consumption and mass producable on-site at a hospital?
For reference ($900/20Ci):
https://www.perkinelmer.com/product/glucose-d-3-3h-hplc-purified-net331c250uc https://www.perkinelmer.com/product/glucose-d-3-3h-hplc-puri...
- eutectic 6y agoWhat about an enzymatic synthesis? Or even partial biosynthesis.
- smartscience 6y agoI'd be willing to have a crack at this if I thought it could help (my background is in nuclear methods for materials characterisation). But I've a feeling that the difference in uptake between cancerous and normal tissue might not be large enough to make this especially useful. Fluorine-18 labelled glucose is used in PET imaging, but not for treatment as far as I'm aware. On the other hand, if a compound can be found that is more selective for the cancer in question, making it radioactive may offer a further improvement.
- whatshisface 6y agoIsotope labeling for imaging requires only a low isotope purity. One radioactive glucose in a vast sea of normal glucose is just fine, because as I'm sure you know the energies of the emitted particles make a very distinct marker.
- IfOnlyYouKnew 6y agoJust grow some sprouts in it? (Not an endorsement of the idea)