What is the process for determining long-term safety of new substances that might end up in the environment? Ah right, just use them until problems show up, the

What is the process for determining long-term safety of new substances that might end up in the environment? Ah right, just use them until problems show up, then try to deny and hide the problems for a few more years. It would not surprise me at all if even in the absence of a smoking gun there are simply a lot of endocrine disruptors at low (even within safe limits, individually) dosages working simultaneously.