You can certainly use the PCIe support on the RPi 4 CM with a SATA controller. Either with a PCIe SATA card on the IO board you linked, or by building a custom

You can certainly use the PCIe support on the RPi 4 CM with a SATA controller. Either with a PCIe SATA card on the IO board you linked, or by building a custom board. The Turing Pi project looks to do that with their next version: https://turingpi.com/v2/ https://turingpi.com/v2/ Should be much more stable than a USB3 connection.