I think in the context of the video clip they are more referring to product/market fit. Many startups fail because they either don't recognize the real problem

I think in the context of the video clip they are more referring to product/market fit. Many startups fail because they either don't recognize the real problem, they build the wrong product to address a problem, or they burn through their cash before they find the point where their solution intersects with the market problem. I believe this is also why domain experience is important to one or more startup founders; the company can build a solution to an understood problem rather than a solution looking for a problem. And don't blame me for the headline; I just took it from Venturebeat :-)