4 ms·

Were it to work in humans, does anyone know if there is any reason such an approach couldn't be extended to other autoimmune disorders which attack the various

Were it to work in humans, does anyone know if there is any reason such an approach couldn't be extended to other autoimmune disorders which attack the various other tissues of the body?

_Microft 6y ago
I think this is what they are eventually aiming for. Half of the authors is affiliated with BioNTech of BioNTech/Pfizer-mRNA-vaccine-fame by the way.
- weaksauce 6y ago
  that's why i've been saying that the mRNA vaccine delivery method could be the next paradigm shift... like antibiotics were.
  - RobertoG 6y ago
    I think that this could be thought as part of a more general revolution: the know-how to program the immune system. This would include things like T-Cells therapy for cancer (1) (1) - https://science.sciencemag.org/content/371/6525/145 https://science.sciencemag.org/content/371/6525/145
  - aaomidi 6y ago
    I don't know why you're being down voted. mRNA and tcell programming is the future of medicine. We may literally not have to worry about pathogen borne, auto immune, or cancer ever again...
- jjcon 6y ago
  When people think vaccine they think, ‘only effective if taken beforehand’. Is that the case for mRNA vaccines?
  - nabla9 6y ago
    Vaccine implies acquired immunity. Exactly same mRNA tech can potentially be used to treat cancer, cardiovascular or metabolic diseases, only the messenger RNA changes. It's probably called mRNA drug instead of mRNA vaccine even if the process is the same. mRNA is tech that BioNTech is developing is completely digital. Once you have the RNA structure in the computer, you can just "print out" drug/vaccine using the same process without changing anything else.
    - andrekandre 6y ago
      i seem to recal that with this technology personalized anti-cancer drugs thst teach the immune system can be created with low cost at some point... seems like a real revolution if true...
  - epilys 6y ago
    If an auto immune disease damages your body but then it stops manifesting, your body will remain damaged. A medical treatment for the caused damage would be called a cure in this case. Vaccines that stop the auto immune response are not cures. A somewhat helpful example is pancreas transplant for type 1 diabetics: the person with the transplant would be "cured" (ie they'd have their own insulin production) but the auto immune disease will destroy the donor pancreas eventually. Hopefully in the future we will have complete, synergistic treatments that take care of both.
    - DubiousPusher 6y ago
      Wouldn't this depend on the type and severity of the autoimmune disorder? Someone with mild Rheumatoid Arthritis for example would be effectively cured if the inflammatory antibodies were supressed as their inflamed joints would largely be able to heal near to their original state.
      - zilian 6y ago
        You are completely right, in many autoimmune disorders if the damage is stopped in time it could be cured.

Were it to work in humans, does anyone know if there is any reason such an approach couldn't be extended to other autoimmune disorders which attack the various other tissues of the body?

_Microft 6y ago

I think this is what they are eventually aiming for. Half of the authors is affiliated with BioNTech of BioNTech/Pfizer-mRNA-vaccine-fame by the way.

weaksauce 6y ago
that's why i've been saying that the mRNA vaccine delivery method could be the next paradigm shift... like antibiotics were.
- RobertoG 6y ago
  I think that this could be thought as part of a more general revolution: the know-how to program the immune system. This would include things like T-Cells therapy for cancer (1) (1) - https://science.sciencemag.org/content/371/6525/145 https://science.sciencemag.org/content/371/6525/145
- aaomidi 6y ago
  I don't know why you're being down voted. mRNA and tcell programming is the future of medicine. We may literally not have to worry about pathogen borne, auto immune, or cancer ever again...
jjcon 6y ago
When people think vaccine they think, ‘only effective if taken beforehand’. Is that the case for mRNA vaccines?
- nabla9 6y ago
  Vaccine implies acquired immunity. Exactly same mRNA tech can potentially be used to treat cancer, cardiovascular or metabolic diseases, only the messenger RNA changes. It's probably called mRNA drug instead of mRNA vaccine even if the process is the same. mRNA is tech that BioNTech is developing is completely digital. Once you have the RNA structure in the computer, you can just "print out" drug/vaccine using the same process without changing anything else.
  - andrekandre 6y ago
    i seem to recal that with this technology personalized anti-cancer drugs thst teach the immune system can be created with low cost at some point... seems like a real revolution if true...
- epilys 6y ago
  If an auto immune disease damages your body but then it stops manifesting, your body will remain damaged. A medical treatment for the caused damage would be called a cure in this case. Vaccines that stop the auto immune response are not cures. A somewhat helpful example is pancreas transplant for type 1 diabetics: the person with the transplant would be "cured" (ie they'd have their own insulin production) but the auto immune disease will destroy the donor pancreas eventually. Hopefully in the future we will have complete, synergistic treatments that take care of both.
  - DubiousPusher 6y ago
    Wouldn't this depend on the type and severity of the autoimmune disorder? Someone with mild Rheumatoid Arthritis for example would be effectively cured if the inflammatory antibodies were supressed as their inflamed joints would largely be able to heal near to their original state.
    - zilian 6y ago
      You are completely right, in many autoimmune disorders if the damage is stopped in time it could be cured.