I think the analogy to your example is to have conducted a larger trial where the dose was given under different weather conditions, or in the case of the real

I think the analogy to your example is to have conducted a larger trial where the dose was given under different weather conditions, or in the case of the real vaccine vary the timing of the 2nd dose. I agree, if experts agree the likelihood that 1 dose is effective and the likelihood of it being ineffective is low, we should do what will save the most lives. This is an emergency.