5 ms·

Live Cells seen with 7x Greater Sensitivity using new Microscopy Technique

84 points by oedmarap 6y ago

jmpeax 6y ago
"Our ADRIFT-QPI method needs no special laser, no special microscope or image sensors; we can use live cells, WE DON’T NEED ANY STAINS OR FLUORESCENCE, and there is very little chance of phototoxicity" Are they suggesting their method can replace immunofluorescence?
zackees 6y ago
The Somatascope did this first: https://youtu.be/KGJW94ciq4c?t=416 https://youtu.be/KGJW94ciq4c?t=416 Before quantum was a buzzword.
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DoofusOfDeath 6y ago
IIUC, the article seems to define the term "light phase" to mean what a layman light me would call "brightness". But it seems crazy to me that they'd overload the term "phase", when it has a very obvious alternative definition in the field of optics. Can someone clarify if that's what the article is actually saying?
- jjoonathan 6y ago
  To detect phase changes you have to turn them into amplitude changes. It then makes sense to call the phase-change-turned-amplitude-change a "phase change." Yes, this elides a critical part of the interpretation, but if we were to insist on carrying around a complete interpretation with every noun we'd wind up with nouns as long as textbooks. Even Germans don't take it that far.
- andai 6y ago
  Had to look up Quantitative phase-contrast microscopy: > Conventional phase contrast microscopy and related methods, such as differential interference contrast microscopy, visualize phase shifts by transforming phase shift gradients into intensity variations. https://en.m.wikipedia.org/wiki/Quantitative_phase-contrast_microscopy https://en.m.wikipedia.org/wiki/Quantitative_phase-contrast_...
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whatshisface 6y ago
I wonder how long it will be before they start using quantum mechanically squeezed states (that trade off position and momentum uncertainty to "beat" the uncertainty principle) like at LIGO to do microscopy.
mycall 6y ago
This reminds me of popular HDR+ techniques used in my smartphone.
frozenport 6y ago
Scientists claim to discover well known HDR technique, publish in Chinese journal. Almost offensively boring work.

84 points by oedmarap 6y ago

"Our ADRIFT-QPI method needs no special laser, no special microscope or image sensors; we can use live cells, WE DON’T NEED ANY STAINS OR FLUORESCENCE, and there is very little chance of phototoxicity" Are they suggesting their method can replace immunofluorescence?

zackees 6y ago

The Somatascope did this first: https://youtu.be/KGJW94ciq4c?t=416 https://youtu.be/KGJW94ciq4c?t=416 Before quantum was a buzzword.

deleted 6y ago
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DoofusOfDeath 6y ago

IIUC, the article seems to define the term "light phase" to mean what a layman light me would call "brightness". But it seems crazy to me that they'd overload the term "phase", when it has a very obvious alternative definition in the field of optics. Can someone clarify if that's what the article is actually saying?

jjoonathan 6y ago
To detect phase changes you have to turn them into amplitude changes. It then makes sense to call the phase-change-turned-amplitude-change a "phase change." Yes, this elides a critical part of the interpretation, but if we were to insist on carrying around a complete interpretation with every noun we'd wind up with nouns as long as textbooks. Even Germans don't take it that far.
andai 6y ago
Had to look up Quantitative phase-contrast microscopy: > Conventional phase contrast microscopy and related methods, such as differential interference contrast microscopy, visualize phase shifts by transforming phase shift gradients into intensity variations. https://en.m.wikipedia.org/wiki/Quantitative_phase-contrast_microscopy https://en.m.wikipedia.org/wiki/Quantitative_phase-contrast_...

deleted 6y ago

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deleted 6y ago
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whatshisface 6y ago

I wonder how long it will be before they start using quantum mechanically squeezed states (that trade off position and momentum uncertainty to "beat" the uncertainty principle) like at LIGO to do microscopy.

mycall 6y ago

This reminds me of popular HDR+ techniques used in my smartphone.

frozenport 6y ago

Scientists claim to discover well known HDR technique, publish in Chinese journal. Almost offensively boring work.