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I agree with this. I don’t think the promise of genomics is even possible because genes (unless it is something simple like a loss of function mutation) don’t
by JohnJamesRambo 6y ago
I agree with this. I don’t think the promise of genomics is even possible because genes (unless it is something simple like a loss of function mutation) don’t work like we think they do on phenotypic expression. Every gene seems to be involved.
https://en.wikipedia.org/wiki/Omnigenic_model https://en.wikipedia.org/wiki/Omnigenic_model
And that doesn’t even begin to touch on epigenetic modifications.
- f6v 6y ago> I don’t think the promise of genomics is even possible It is possible, but building a whole-organism model requires huge amounts of data for each individual, which isn’t economically feasible at the moment. The 1000$ genome is there, but we need to bring it down to 10$ or less. That is one of the reasons why modern bioinformatics is relying on mechanistic statistical models so much. You have to be incredibly smart with your models since there’s so few samples to work with.