I think it's better to create a virtualenv for each project and install tox and other project dependencies there. In addition, I'm not sure tox-pyenv is requir

I think it's better to create a virtualenv for each project and install tox and other project dependencies there. In addition, I'm not sure tox-pyenv is required. I use tox with multiple pyenv-installed Python versions and have never used it. Base: - install homebrew - brew install openssl readline sqlite3 xz zlib # recommended - brew install pyenv - pyenv install <version> # for one or more versions Project: - create/clone project directory - cd project directory - pyenv local x.y.z x.y.z ... # include each version the project supports - python3 -m venv .venv # create virtualenv for project using one of the pyenv versions - install the project into the virtualenv - install any additional dependencies into this virtualenv too, if necessary Edit: I'd also add that if you do need a tool to be installed globally, it's better to use pipx or pip with --user. It's generally not a good idea to install things into a system-level Python. https://pipxproject.github.io/pipx/ https://pipxproject.github.io/pipx/