In the case of highly vulnerable patients the death rate is vastly higher, easily into the double-digits, e.g. https://www.manchester.ac.uk/discover/news/frailt

In the case of highly vulnerable patients the death rate is vastly higher, easily into the double-digits, e.g. https://www.manchester.ac.uk/discover/news/frailty-old-age-and-comorbidity-main-predictors-of-death-from-covid-19/ https://www.manchester.ac.uk/discover/news/frailty-old-age-a... - with extreme risk factors and old age the death rate is staggering. If you had e.g. a 75% chance of death but the vaccine had a 0.01% chance of killing or seriously impairing you, even taking into account all the issues and the risk of actually catching it the risk seems worthwhile. However this discussion does make me think that the candidate range is going to be pretty narrow, and of course all concerned would have to be able and willing to give informed consent many of whom presumably would not.