3 ms·
I generally agree with you. Keep in mind I'm at 'stayed at the Holiday Inn' levels of competence here, but in my mind the spike proteins that are generated by
by jcims 6y ago
I generally agree with you. Keep in mind I'm at 'stayed at the Holiday Inn' levels of competence here, but in my mind the spike proteins that are generated by an actual infection don't typically leave the cytoplasm detached from the rest of the virus. This could be incorrect.
If that's generally true, the difference here would be that the part of the spike protein topology that is typically bound to other proteins in an actual infection would be accessible to the immune system in the case of a vaccination. I think that is where the differential risk could occur with a vaccination that wouldn't occur with an actual infection (however small that might be).
In my daughter's case, something happened when she was about 14 years old that caused her body to determine that the beta cells in her pancreas were invaders and have to die, so I'm just tuned into this kind of possible side effect.
- flobosg 6y ago> (...) but in my mind the spike proteins that are generated by an actual infection don't typically leave the cytoplasm detached from the rest of the virus. If the virus is destroyed and released into the extracellular environment, its proteins can dissociate and are further fragmented and processed by the immune system. What’s usually presented to T cells are small antigen pieces as opposed to the whole virus/protein.
- jcims 6y agoThis is a great point thank you.
- sampo 6y ago> in my mind the spike proteins that are generated by an actual infection don't typically leave the cytoplasm detached from the rest of the virus Virus takes over the cell, makes the cell to manufacture components of the virus and to assemble viruses, until this disrupts the cell so bad that the cell dies and typically bursts. Surely at this point, not only assembled viruses, but also components at different stages of production, are released? https://en.wikipedia.org/wiki/Introduction_to_viruses#Life-cycle https://en.wikipedia.org/wiki/Introduction_to_viruses#Life-c...
- jcims 6y agoThank you. I knew this at some level but this (amazing) animation of HIV got me on a track of thinking that the viruses have a mechanism for exiting the cell without destroying it: https://vimeo.com/260291607 https://vimeo.com/260291607
- sampo 6y agoLike the Wikipedia article says, most viruses make the cell burst. Some, like HIV, have less destructive methods. I could not find how SARS-CoV-2 does it.
- gingerlime 6y ago> Keep in mind I'm at 'stayed at the Holiday Inn' levels of competence here OT, but what does this mean or refer to? I'm curious :)
- jcims 6y agohttps://youtu.be/eHCTaUFXpP8 https://youtu.be/eHCTaUFXpP8 Corny but fun, they had a few good ones.