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What do these inhibitory neurons do to manage short-term memories?

by babesh 6y ago

jand 6y ago
Optimistic guess: This information can be found in the paywall'ed article at [1] > Dissecting our recurrent neural network model revealed strong inhibitory-to-inhibitory connections underlying a disinhibitory microcircuit as a critical component for long neuronal timescales and WM maintenance If the article is worth the money, i would expect it to go into detail on it. [1] https://www.nature.com/articles/s41593-020-00753-w https://www.nature.com/articles/s41593-020-00753-w
- greyface- 6y ago
  https://sci-hub.se/https://www.nature.com/articles/s41593-020-00753-w https://sci-hub.se/https://www.nature.com/articles/s41593-02...
subroutine 6y ago
This is explained in the Nature article (summary on page 133) and shown as a diagrams in figure 6... > In summary, these findings imply that robust inhibition of oppositely tuned inhibitory subpopulations is critical for memory maintenance in our RNN model. For example, a positive cue stimulus activates the inhibitory and excitatory subgroups selective for that stimulus and deactivates the negative stimulus subgroups. During the delay period, the inhibition strength between these two inhibitory subgroups dictates the stability of the cue-specific activity patterns generated during the stimulus window. The positive feedback provided by the similarly tuned excitatory neurons sustains the stimulus-specific activity of the inhibitory subgroups.
- goldenshale 6y ago
  My intuitive understanding of these findings is that short term memory works by maintaining a consistent firing pattern in a particular region of the prefrontal cortex. By default a given firing pattern might activate other patterns because neurons tend to be a part of multiple potential pattern groups, and so left unchecked it could result in an unstable, random walk type of sequence. To stay in the attractor of one memory though, inhibitory neurons are used to turn off everything that isn't a part of the memory, thereby allowing it to remain in a more steady state.
  - subroutine 6y ago
    To further clarify, I believe the authors are advocating a WM model where an excitatory subnet (activated by a Positive cue) sustains its firing (in the absence of that cue; the Delay period) by activating inhibitors of its own inhibitors. (these inhibitory subnets, like goldenshale mentions, also seem to inhibit excitatory subnets, diffusely). model diagram: https://i.ibb.co/nrh1pVJ/figs.png https://i.ibb.co/nrh1pVJ/figs.png

What do these inhibitory neurons do to manage short-term memories?

by babesh 6y ago

What do these inhibitory neurons do to manage short-term memories?

jand 6y ago

Optimistic guess: This information can be found in the paywall'ed article at [1] > Dissecting our recurrent neural network model revealed strong inhibitory-to-inhibitory connections underlying a disinhibitory microcircuit as a critical component for long neuronal timescales and WM maintenance If the article is worth the money, i would expect it to go into detail on it. [1] https://www.nature.com/articles/s41593-020-00753-w https://www.nature.com/articles/s41593-020-00753-w

greyface- 6y ago
https://sci-hub.se/https://www.nature.com/articles/s41593-020-00753-w https://sci-hub.se/https://www.nature.com/articles/s41593-02...

subroutine 6y ago

This is explained in the Nature article (summary on page 133) and shown as a diagrams in figure 6... > In summary, these findings imply that robust inhibition of oppositely tuned inhibitory subpopulations is critical for memory maintenance in our RNN model. For example, a positive cue stimulus activates the inhibitory and excitatory subgroups selective for that stimulus and deactivates the negative stimulus subgroups. During the delay period, the inhibition strength between these two inhibitory subgroups dictates the stability of the cue-specific activity patterns generated during the stimulus window. The positive feedback provided by the similarly tuned excitatory neurons sustains the stimulus-specific activity of the inhibitory subgroups.

goldenshale 6y ago
My intuitive understanding of these findings is that short term memory works by maintaining a consistent firing pattern in a particular region of the prefrontal cortex. By default a given firing pattern might activate other patterns because neurons tend to be a part of multiple potential pattern groups, and so left unchecked it could result in an unstable, random walk type of sequence. To stay in the attractor of one memory though, inhibitory neurons are used to turn off everything that isn't a part of the memory, thereby allowing it to remain in a more steady state.
- subroutine 6y ago
  To further clarify, I believe the authors are advocating a WM model where an excitatory subnet (activated by a Positive cue) sustains its firing (in the absence of that cue; the Delay period) by activating inhibitors of its own inhibitors. (these inhibitory subnets, like goldenshale mentions, also seem to inhibit excitatory subnets, diffusely). model diagram: https://i.ibb.co/nrh1pVJ/figs.png https://i.ibb.co/nrh1pVJ/figs.png