Thanks! That worked. I also tried adding the line to a new file /etc/binfmt.d/APE.conf, but it didn't seem to work (after a reboot); after renaming the file to

Thanks! That worked. I also tried adding the line to a new file /etc/binfmt.d/APE.conf, but it didn't seem to work (after a reboot); after renaming the file to zz_APE.conf, it did work after a reboot. systemd's binfmt.d registers files in alphabetical filename order, so I'm guessing it's important that /usr/lib/binfmt.d/wine.conf is registered before the APE handler, meaning its filename must be alphabetically after "wine.conf".