3 ms·
> So, the toxic dose of Tylenol is only 2.5X the active dose The effective dose starts at 500mg. Most people are likely going to be taking 1 or 2x 500mg tablet
by lol768 6y ago
> So, the toxic dose of Tylenol is only 2.5X the active dose
The effective dose starts at 500mg. Most people are likely going to be taking 1 or 2x 500mg tablets for acute issues - and I'd argue that's often enough for most cases where you want short-term analgesia. Both 500mg and 1000mg will improve SPRID6 scores (dental; https://www.cadth.ca/sites/default/files/pdf/htis/june-2016/RC0786%20Acetaminophen%20Dose%20Final.pdf https://www.cadth.ca/sites/default/files/pdf/htis/june-2016/...).
Where I've complained of medium term pain (expected duration: weeks to months) my GP has suggested NSAIDs instead. They're not without their own problems but I think I'd personally prefer their safety profile to long-term Paracetamol.
- arcticbull 6y agoAll Tylenol figures are in daily totals, and Tylenol lasts 4 hours. 500-1000mg taken 4x daily is 2-4g. That makes the therapeutic index 1.875-2.5 as I mentioned. 12g over 2 days is 1.5X. Again that’s without alcohol which folks do not seem to appreciate. People can and do exceed these numbers hence the 50,000 ER visits per year. It is the leading cause of acute liver failure in the United States. The bar shouldn’t be “often enough for most cases” when 1.5X the dose for 2 days can kill you. Either the safety margin is too low or the warnings aren’t nearly big enough, but the numbers don’t lie, the status quo is bad. Especially when the alternatives require way less diligence on your part and are sold as equivalent adjacent products.
- apple4ever 6y agoThat's exactly why I take NSAIDs over Tylenol if I can.