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Nice article. There are more interesting things to say about RNA that makes it a bit less like code - for example that it too can fold to a 3d structure, with s
by yread 6y ago
Nice article. There are more interesting things to say about RNA that makes it a bit less like code - for example that it too can fold to a 3d structure, with some cases that can cause problems - hairpins for example where the sequence is palindrome-like (in the complementing letters) ACG followed by CGU can fold onto itself. This caused the problems with the initial batch of CDC's PCR tests
- LeanderK 6y agoas I understood it from the "universal table for mapping RNA codons to amino acids" one can encode the same information differently. So is it just possible define the information you want to encode and use a computer to calculate the correct encoding so that things don't get tangled up?
- flobosg 6y agoYes. Codon optimization is a routine procedure when designing genes and is mentioned in the article. Methionine and tryptophan, however, cannot be optimized since they only have one codon each.
- divbzero 6y agoAnd on top of that RNA can exhibit non-canonical base pairing like G-U. [1] [1]: https://commons.wikimedia.org/wiki/File:Wobble.svg https://commons.wikimedia.org/wiki/File:Wobble.svg