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Thank you! I came here to ask the same question. Now that we are producing and injecting industrial quantities of Ψ, any chance this will get incorporated in a

Thank you! I came here to ask the same question. Now that we are producing and injecting industrial quantities of Ψ, any chance this will get incorporated in actual viruses or maybe teach the immune system not to ignore it (or maybe even go crazy about it)?

laughingmonkey1 6y ago
The article directly addresses that question, saying it's highly unlikely because the viruses don't have the machinery to manufacture it.
scotty79 6y ago
I think there's no risk since cells can't make Ψ, and probaby Ψ is not super durable as a chemical.
- flobosg 6y ago
  > cells can't make Ψ Pseudouridine is the most common RNA modification in cells, actually. They produce it all the time. > and probaby Ψ is not super durable as a chemical. Quite the opposite. Pseudouridine usually increases the stability of the RNA molecule it modifies.
  - HerrmannM 6y ago
    Taken from the article (probably after an update): Many people have asked, could viruses also use the Ψ technique to beat our immune systems? In short, this is extremely unlikely. Life simply does not have the machinery to build 1-methyl-3’-pseudouridylyl nucleotides. Viruses rely on the machinery of life to reproduce themselves, and this facility is simply not there. The mRNA vaccines quickly degrade in the human body, and there is no possibility of the Ψ-modified RNA replicating with the Ψ still in there. “No, Really, mRNA Vaccines Are Not Going To Affect Your DNA“ is also a good read.
    - flobosg 6y ago
      I should have cleared that up. Normally Ψ would stand for pseudouridine, but the vaccine has a further modified base, 1-methylpseudouridine.
- coldtea 6y ago
  Cells might not, but people can...
metta2uall 6y ago
They're injecting already-made Ψ, not any of the genetic instructions that would enable cells/viruses to make their own Ψ. But the broader concern about advances in biotech being potentially very dangerous is I think a very good one..

laughingmonkey1 6y ago

The article directly addresses that question, saying it's highly unlikely because the viruses don't have the machinery to manufacture it.

scotty79 6y ago

I think there's no risk since cells can't make Ψ, and probaby Ψ is not super durable as a chemical.

flobosg 6y ago
> cells can't make Ψ Pseudouridine is the most common RNA modification in cells, actually. They produce it all the time. > and probaby Ψ is not super durable as a chemical. Quite the opposite. Pseudouridine usually increases the stability of the RNA molecule it modifies.
- HerrmannM 6y ago
  Taken from the article (probably after an update): Many people have asked, could viruses also use the Ψ technique to beat our immune systems? In short, this is extremely unlikely. Life simply does not have the machinery to build 1-methyl-3’-pseudouridylyl nucleotides. Viruses rely on the machinery of life to reproduce themselves, and this facility is simply not there. The mRNA vaccines quickly degrade in the human body, and there is no possibility of the Ψ-modified RNA replicating with the Ψ still in there. “No, Really, mRNA Vaccines Are Not Going To Affect Your DNA“ is also a good read.
  - flobosg 6y ago
    I should have cleared that up. Normally Ψ would stand for pseudouridine, but the vaccine has a further modified base, 1-methylpseudouridine.
coldtea 6y ago
Cells might not, but people can...

metta2uall 6y ago

They're injecting already-made Ψ, not any of the genetic instructions that would enable cells/viruses to make their own Ψ. But the broader concern about advances in biotech being potentially very dangerous is I think a very good one..