No, there really isn't. There are apps that I've bought through the App Store, some of which I actually use at work, and I don't really see value in "avoiding"

No, there really isn't. There are apps that I've bought through the App Store, some of which I actually use at work, and I don't really see value in "avoiding" apps just because they're in the App Store. But most of what I use is outside it, and if an app is available both inside and outside -- as many are -- I usually get the direct sale one. (While I shouldn't speak for the OP, I'm a little suspicious that this is the "Big Brother Apple is going to lock down macOS just like iOS" narrative popping up again.)