I'd personally go with ZFS. There are already people in your field using ZFS to ensure the integrity of their data (based on past conversations here on HN). I

I'd personally go with ZFS. There are already people in your field using ZFS to ensure the integrity of their data (based on past conversations here on HN). I've used both ZFS and Btrfs extensively. Only Btrfs has lost data and behaved badly. I would highly recommend evaluating ZFS.