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Yeah PEG allergies are a nonstory. That said, actual nanoparticles should usually give people pause. Nanotoxicity is a poorly understood subject that only recen
by akiselev 6y ago
Yeah PEG allergies are a nonstory. That said, actual nanoparticles should usually give people pause. Nanotoxicity is a poorly understood subject that only recently started getting some of the attention it deserves. Usually, when people talk about nanoparticles in context, they're made up of rigid or semi-rigid structures (which PEG is not) that can turn into asbestos-like carcinogens after a little wear and tear.
- Puts 6y agoHow can it be a nonstory when the experts in the article are so divided? One said they had to stop trails with PEG drugs because someone died, and another says they are not the cause of allergic reactions at all, while a third says yes they are but they are triggered by different antibodies. Seems like we actually don't know much about this at all then?
- akiselev 6y agoA cursory look at the literature [1] shows five confirmed recent cases of PEG allergy. PEG is used all over the place: taken internally in several OTC laxatives, applied externally in cosmetics and personal lubricant, vaporized and inhaled in electronic cigarettes, and as a solvent in many industrial processes. If PEG allergies were a serious concern, it would have risen about the noise floor a long time ago since it causes an acute reaction. It's definitely not worth stopping clinical trials for five total confirmed cases in the medical literature, especially if those trials target a global emergency like COVID. For comparison: you'd get at least five confirmed cases of peanut allergies just by spraying down a single decent sized elementary school with peanut dust. [1] https://www.sciencedirect.com/science/article/pii/S2213219820310072 https://www.sciencedirect.com/science/article/pii/S221321982...
- gnusty_gnurc 6y ago> It's definitely not worth stopping clinical trials Did anyone suggest this?