4 ms·
My understanding is as long as the variant has the same spike protein, vaccines "should" remain effective. So while trials haven't been done yet to verfiy the v
by SifJar 6y ago
My understanding is as long as the variant has the same spike protein, vaccines "should" remain effective. So while trials haven't been done yet to verfiy the vaccines are still effective, I'm assuming the spike protein has been observed to be the same so there's no reason to suggest vaccines wouldn't be effective.
EDIT: Actually, sounds like a couple of the mutations are in the spike protein and there is some evidence of reduced antibody effectiveness against the mutated version.
- lbeltrame 6y agoN501Y is properly neutralized by vaccination (there's a paper in Science with these data, but I don't have a link handy right now). The deletion seems to reduce antibody neutralization, but: - In the preprint where this was shown, only 4 convalescent sera were tested; - The same 4 sera had large variation in neutralization activity per se; - There is no investigation on potential impaired T cell reactivity (cellular immunity): FTR, the "mink mutation", although it exhibited slightly lower antibody neutralization, did not change the reaction of T cells to it.
- lbeltrame 6y agoI realized I made a mistake here but can't correct now: the sera used were 5, not 4.
- sjg007 6y agoThis is being studied.