It's suspected that this mutation arose from a single patient who had a long case of COVID-19. Here's an interesting pre-print study on an individual (not the o

It's suspected that this mutation arose from a single patient who had a long case of COVID-19. Here's an interesting pre-print study on an individual (not the one from this mutation) who harboured many mutations over a 101-day period. [https://www.cogconsortium.uk/news_item/persistent-sars-cov-2-infection-and-viral-evolution-tracked-in-an-immunocompromised-patient/ https://www.cogconsortium.uk/news_item/persistent-sars-cov-2...] In terms of this strain, the actual rate of mutation is higher (5.6E-4 nucleotide changes/site/year vs 5.3E-4) [https://virological.org/t/preliminary-genomic-characterisation-of-an-emergent-sars-cov-2-lineage-in-the-uk-defined-by-a-novel-set-of-spike-mutations/563 https://virological.org/t/preliminary-genomic-characterisati...]