3 ms·

Would this be an accurate summary: „There is a slim chance the mRNA is incorporated into the DNA if there is an ongoing infection with a retro-virus during vac

Would this be an accurate summary: „There is a slim chance the mRNA is incorporated into the DNA if there is an ongoing infection with a retro-virus during vaccination“?

rolph 6y ago
somewhat less than slim. the RNA must interact with retroviral reverse transcriptase in a manner that makes a functional complex or it will just be snipped apart and decycled like garbage. RNA will fold and produce 2' structure this has interesting consequence. catalytic RNA, structural RNA, stabilizing or protective RNA.. [0] https://www.youtube.com/watch?v=RYwVnzYf4V8 https://www.youtube.com/watch?v=RYwVnzYf4V8 [1] https://pubmed.ncbi.nlm.nih.gov/20358252/ https://pubmed.ncbi.nlm.nih.gov/20358252/ [2] https://sci-hub.st/https://doi.org/10.1007/s00018-010-0346-2 https://sci-hub.st/https://doi.org/10.1007/s00018-010-0346-2 [PDF] [3] https://www.researchgate.net/profile/Tania_Matamoros2/publication/221917300_Reverse_Transcriptase_and_Retroviral_Replication/links/56e6985e08ae65dd4cc1ad4f/Reverse-Transcriptase-and-Retroviral-Replication.pdf https://www.researchgate.net/profile/Tania_Matamoros2/public... [PDF] from the paper [3] above: "Reverse transcription initiates after binding of a cellular tRNA primer (in HIV-1, tRNA Lys,3 ), to the primer binding site (PBS). The PBS is a sequence of 18 nucleotides, located downstream of the 5’-end of the genomic RNA. The viral RNA that serves as template for reverse transcription is flanked by repeat (R) sequences at its 5 ́ and 3 ́ termini." the vaccine mRNA does not meet these requirements. retroviral RNA is configured to function with the reverse transcriptase. Promiscuity to include other RNA is exceptional not common. virally infected cells also undergo changes that exclude further infection so they have the cell to themselves. i would like to say zero chance, but life is in the business of sidestepping the rules to its advantage, however you have a much greater chance of being attacked by a shark while hiking the sahara dunes.
- MrBuddyCasino 6y ago
  Thanks, appreciated.
- MrBuddyCasino 6y ago
  Interestingly, it seems this has already happened with the virus being integrated into human DNA in rare cases, though apparently to no ill effect: https://www.sciencemag.org/news/2020/12/coronavirus-may-sometimes-slip-its-genetic-material-human-chromosomes-what-does-mean https://www.sciencemag.org/news/2020/12/coronavirus-may-some...
  - rolph 6y ago
    this is a preview paper. the situation was artificially created. the retroviral Reverse Transcriptase must be present in the individual cells also infected with the covid virus.

Would this be an accurate summary: „There is a slim chance the mRNA is incorporated into the DNA if there is an ongoing infection with a retro-virus during vaccination“?

rolph 6y ago

somewhat less than slim. the RNA must interact with retroviral reverse transcriptase in a manner that makes a functional complex or it will just be snipped apart and decycled like garbage. RNA will fold and produce 2' structure this has interesting consequence. catalytic RNA, structural RNA, stabilizing or protective RNA.. [0] https://www.youtube.com/watch?v=RYwVnzYf4V8 https://www.youtube.com/watch?v=RYwVnzYf4V8 [1] https://pubmed.ncbi.nlm.nih.gov/20358252/ https://pubmed.ncbi.nlm.nih.gov/20358252/ [2] https://sci-hub.st/https://doi.org/10.1007/s00018-010-0346-2 https://sci-hub.st/https://doi.org/10.1007/s00018-010-0346-2 [PDF] [3] https://www.researchgate.net/profile/Tania_Matamoros2/publication/221917300_Reverse_Transcriptase_and_Retroviral_Replication/links/56e6985e08ae65dd4cc1ad4f/Reverse-Transcriptase-and-Retroviral-Replication.pdf https://www.researchgate.net/profile/Tania_Matamoros2/public... [PDF] from the paper [3] above: "Reverse transcription initiates after binding of a cellular tRNA primer (in HIV-1, tRNA Lys,3 ), to the primer binding site (PBS). The PBS is a sequence of 18 nucleotides, located downstream of the 5’-end of the genomic RNA. The viral RNA that serves as template for reverse transcription is flanked by repeat (R) sequences at its 5 ́ and 3 ́ termini." the vaccine mRNA does not meet these requirements. retroviral RNA is configured to function with the reverse transcriptase. Promiscuity to include other RNA is exceptional not common. virally infected cells also undergo changes that exclude further infection so they have the cell to themselves. i would like to say zero chance, but life is in the business of sidestepping the rules to its advantage, however you have a much greater chance of being attacked by a shark while hiking the sahara dunes.

MrBuddyCasino 6y ago
Thanks, appreciated.
MrBuddyCasino 6y ago
Interestingly, it seems this has already happened with the virus being integrated into human DNA in rare cases, though apparently to no ill effect: https://www.sciencemag.org/news/2020/12/coronavirus-may-sometimes-slip-its-genetic-material-human-chromosomes-what-does-mean https://www.sciencemag.org/news/2020/12/coronavirus-may-some...
- rolph 6y ago
  this is a preview paper. the situation was artificially created. the retroviral Reverse Transcriptase must be present in the individual cells also infected with the covid virus.