I think RNAs are great as a cell therapy. Not necessarily mRNAs, but other ncRNAs which can be used to silence enhancers. This would be great for many diseases.

I think RNAs are great as a cell therapy. Not necessarily mRNAs, but other ncRNAs which can be used to silence enhancers. This would be great for many diseases. mRNAs are great as a vaccine to trigger an anti-cancer response, combined with checkpoint inhibitors. The big challenge is to choose a good personalized mix of peptides (encoded as mRNAs) in a way that scales to thousands of patients.