3 ms·
I don't know how Moderna was made, but the Pfizer vaccine is a modified spike protein: they use two edits to lock it in a pre-fusion conformation. Maybe this is
by tehjoker 6y ago
I don't know how Moderna was made, but the Pfizer vaccine is a modified spike protein: they use two edits to lock it in a pre-fusion conformation. Maybe this is easy to model in software, but I suspect that does take a little bit of trial and error to confirm it works in vitro too.
- blackbear_ 6y agoModerna did that too [1]. I have no clue how they found the mutation but it was already known for a few years [2,3] [1] https://www.biorxiv.org/lookup/doi/10.1101/2020.06.11.145920 https://www.biorxiv.org/lookup/doi/10.1101/2020.06.11.145920 [2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200764/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200764/ [3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5223232/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5223232/