This appears to be a potential alternative to selective amplification. https://www.wikiwand.com/en/Polymerase_chain_reaction#/Selective_DNA_isolation https://ww

This appears to be a potential alternative to selective amplification. https://www.wikiwand.com/en/Polymerase_chain_reaction#/Selective_DNA_isolation https://www.wikiwand.com/en/Polymerase_chain_reaction#/Selec... Instead of pre-processing the DNA by preferentially amplifying the DNA segments of interest (so that 99%+ of what you sequence is stuff you want), this software/hardware combo sequences the first N bases of each molecule, and then moves on to the next molecule if it doesn't match any expected sequences. If you're sequencing molecules over >200bp, being able to eject the molecule in the first ~10bp could be a very big speedup. Our lab already has sub-1 day processing times for this type of analysis, but I believe the traditional sequencer machine we use (an Illumina MiSeq) is likely more expensive and more cumbersome than the portable solution described here.