Having a 100x multiples for clearance leaves a large safety margin but again take water, 0.5L per day is good, 1L won't kill you but above 8L people have known

Having a 100x multiples for clearance leaves a large safety margin but again take water, 0.5L per day is good, 1L won't kill you but above 8L people have known to die. That's only 16x. People also get get cyanide poisoning from raw almond smoothies, alcohol poisoning from binge drinking and caffeine poisoning at and also less than 100x regular portion. Radiation too, 2-30 is pretty typical and no statistically significant results but bring that to 300 and you get measurable increase in cancer rates.