A more user-friendly approach would be to do something similar to what soundcloud does with comments - I think the ability for people to leave inline comments w

A more user-friendly approach would be to do something similar to what soundcloud does with comments - I think the ability for people to leave inline comments within a video would rock. You could still tie this in with tweets, with a link to jump straight to the part of the video being commented on. You'd also be adding more value by actually encouraging discussion on the content, like a disqus for video.