Many medical professionals recommend against alternating, not because it is unsafe but because the mental overhead and differing schedules depending on dose can

Many medical professionals recommend against alternating, not because it is unsafe but because the mental overhead and differing schedules depending on dose can lead to mistakes and lead to accidental overdose if you aren’t paying attention or writing it down. Also, make sure you are only taking one NSAID (acetylsalicylic acid/asprin, ibuprofen/Advil/Motrin, naproxen sodium/Aleve) if you are alternating painkillers - if you take excedrin/generic “migraine” formula you are already getting a dose of asprin and should not take anything else with it.