3 ms·

These are great questions. Another one since we are talking about editing the programming “code” of the human body is: what if we got it wrong? What sorts of “b

These are great questions. Another one since we are talking about editing the programming “code” of the human body is: what if we got it wrong? What sorts of “bugs” might occur in execution or through unforeseen interactions?

exmadscientist 6y ago
> Another one since we are talking about editing the programming “code” of the human body is ...no? This is not gene therapy. The effects of receiving a mRNA vaccine will, apart from training the immune system (which was the whole point), be next to nothing. Your body is continually being bombarded with random foreign DNA and RNA. That's just how life on Earth works. Yes, introducing a big pile of it at once is not normal... but it's a difference of degree, not something completely new. If anything, problems are more likely to derive from the lipid bubbles used (at least by Moderna) to package and transport the mRNA.
- whycombagator 6y ago
  > If anything, problems are more likely to derive from the lipid bubbles used (at least by Moderna) to package and transport the mRNA. Noob here, could you expand on that?
  - aponia 6y ago
    Here is an article on Covid vaccines, and the second link is from its references, and explains lipid nanoparticles used in these vaccines. Both the Pfizer and Moderna vaccines use lipid nanoparticles and are very similar in their designs. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7583697/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7583697/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624045/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624045/ ______________________________________________________ edit: Here is more specific information on lipid nanoparticles in RNA vaccines, which explains that RNA vaccines that involve lipid nanoparticles tend to cause a local inflammatory effect, i.e. shoulder soreness. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6963972/#sec3-vaccines-07-00132title https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6963972/#sec3-v...
- djsumdog 6y ago
  So what is causing the side effects people in the studies are suffering? There seems to be a lot of concern on people not wanting the second dose. I know flu shots will always make the injected arm hurts for days (never have that reaction with other vaccines for some reason). If this is just creating proteins and not an inactivated virus, what's causing the responses that are being reported?
nthj 6y ago
This vaccine is like providing a machine learning model another website to read, after reading millions of websites. It is absolutely not anything like merging a patch into the master branch.

exmadscientist 6y ago

> Another one since we are talking about editing the programming “code” of the human body is ...no? This is not gene therapy. The effects of receiving a mRNA vaccine will, apart from training the immune system (which was the whole point), be next to nothing. Your body is continually being bombarded with random foreign DNA and RNA. That's just how life on Earth works. Yes, introducing a big pile of it at once is not normal... but it's a difference of degree, not something completely new. If anything, problems are more likely to derive from the lipid bubbles used (at least by Moderna) to package and transport the mRNA.

whycombagator 6y ago
> If anything, problems are more likely to derive from the lipid bubbles used (at least by Moderna) to package and transport the mRNA. Noob here, could you expand on that?
- aponia 6y ago
  Here is an article on Covid vaccines, and the second link is from its references, and explains lipid nanoparticles used in these vaccines. Both the Pfizer and Moderna vaccines use lipid nanoparticles and are very similar in their designs. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7583697/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7583697/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624045/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624045/ ______________________________________________________ edit: Here is more specific information on lipid nanoparticles in RNA vaccines, which explains that RNA vaccines that involve lipid nanoparticles tend to cause a local inflammatory effect, i.e. shoulder soreness. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6963972/#sec3-vaccines-07-00132title https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6963972/#sec3-v...
djsumdog 6y ago
So what is causing the side effects people in the studies are suffering? There seems to be a lot of concern on people not wanting the second dose. I know flu shots will always make the injected arm hurts for days (never have that reaction with other vaccines for some reason). If this is just creating proteins and not an inactivated virus, what's causing the responses that are being reported?

nthj 6y ago

This vaccine is like providing a machine learning model another website to read, after reading millions of websites. It is absolutely not anything like merging a patch into the master branch.