3 ms·

Have they released the rna sequences of the pfizer and moderna vaccines? I could not find them in the patents or supplementary information in the journal papers

• ceejayoz 6y ago
  > It would go a long way towards public trust if they released this information. No, it wouldn't. The goal posts would immediately move.
  • kleton 6y ago
    Normal drugs are required to have the chemical structure in the packaging. I wonder why they are allowed to release this one without similar chemical information.
    • ceejayoz 6y ago
      The Pfizer vaccine: https://go.drugbank.com/drugs/DB15696 https://go.drugbank.com/drugs/DB15696 > BNT162b2 is a nucleoside modified mRNA (modRNA) vaccine encoding an optimized full-length version of the SARS-CoV-2 spike (S) protein... which appears to be entirely public (along with the rest of the SARS-CoV-2 genome): https://www.ncbi.nlm.nih.gov/gene/43740568 https://www.ncbi.nlm.nih.gov/gene/43740568
      • cblconfederate 6y ago
        the BNT162b2 sequence itself is not available though
        • ceejayoz 6y ago
          The sequence is that of the protein. That's how it works. The vaccine contains the mRNA sequence for the protein, so cells produce it, triggering an immune response. The "nucleotide modified" bit just means they replace some nucleotides with nucleotide isomers like pseudouridine (https://en.wikipedia.org/wiki/Pseudouridine https://en.wikipedia.org/wiki/Pseudouridine) to keep the vaccine itself from being attacked. The sequence remains the same.