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Yes, that makes sense. I was just wondering if the target virus is already RNA encoded, if that provides any shortcuts. It sounds like maybe not.
by jbaudanza 6y ago
Yes, that makes sense. I was just wondering if the target virus is already RNA encoded, if that provides any shortcuts. It sounds like maybe not.
- rolph 6y agowhile it is possible to harvest SARS genomic RNA and excise dangerous components this is expensive time and money wise and dangerous, this reduces to the better approach being a synthetic novel S protien manufactured from raw materials.
- nicwilson 6y agoIt doesn't. The vaccine is a piece of mRNA (in this case part of the spike protein) which has a cap on one end to stop degradation from the start of the message (which would garble it completely). This piece of RNA is not replicated. Whereas the virus encodes the whole spike, the capsid protein and whatever else the virus needs to replicate like promoter sequences and an origin of replication. It is much larger and is replicate. Basically it skips all the viral machinery and just codes for a small piece that identifies the virus to the immune system.