4 ms·
Nature has a decent article on this: https://www.nature.com/articles/d41586-020-02544-6 https://www.nature.com/articles/d41586-020-02544-6 Apparently we have l
by brian_cloutier 6y ago
Nature has a decent article on this: https://www.nature.com/articles/d41586-020-02544-6 https://www.nature.com/articles/d41586-020-02544-6
Apparently we have little idea whether D614G is more infectious but that is hard to believe given that it has so thoroughly outcompeted other strains.
- twic 6y agoHard to believe, but true - because it didn't outcompete other alleles, it was just in the right place at the right time, as has been carefully documented: https://twitter.com/ballouxfrancois/status/1331669118001537024 https://twitter.com/ballouxfrancois/status/13316691180015370... Still, assuming that massive success is due to competitive advantage rather than random chance is extremely on-brand for HN.
- Throwaway1771 6y agoTotally uncalled for, and hilarious, knifejab by a man in black pajamas.
- brian_cloutier 6y agoThe founder effect doesn't seem capable of explaining the spread of D614G given that it has replaced other varients in every place it has been introduced to, and that it has even doubled back and outcompeted other variants even when those variants were introduced far before D614G. I'll read this paper, though, to get a better idea of what they're claiming; thanks for the link. You have assumed I'm ignorant when you could have attempted to understand why I believe the things I do which seems at least as big a mistake as the one you accused me of making.
- rolph 6y agothe D614G strain has a loose binding domain in its spike. this modifies what was a specific key into a lockpick. this allows the virus to bind to a number of allelic versions of ACE2 rather than one or few specifics. thus promiscuous binding.