4 ms·

I'm glad to learn about alpha-liproic acid, and on the same theme the beta (and alpha1) blocker Carvedilol taken 1h before has been found [0] to reduce hyperthe

I'm glad to learn about alpha-liproic acid, and on the same theme the beta (and alpha1) blocker Carvedilol taken 1h before has been found [0] to reduce hyperthermia and other cardiotoxic effects of MDMA without "affecting the subjective effects". This is your threadly reminder to practice harm reduction if you plan to take neuro- and cardiotoxic drugs like MDMA =) [0] https://pubmed.ncbi.nlm.nih.gov/22404145/ https://pubmed.ncbi.nlm.nih.gov/22404145/

bennysonething 6y ago
Genuine question, is mdma cardio toxic? Thought that was cocaine?
- pvarangot 6y ago
  It's not clear it's cardiotoxic even on heavy users. Most research points out that it is, but the mechanism is not well understood so it may be a correlation as most heavy users will not be leading a healthy vascular life.
  - meowface 6y ago
    Importantly, it may be neurotoxic for heavy users, though. It's actually probably by far the most neurotoxic drug that's commonly used recreationally. (Believed to be due in part to the acute serotonin release, and reactive oxygen species, and risk of overheating.) This is not at all to scaremonger - just to encourage people to always research things very carefully before they consume them. https://rollsafe.org/how-to-take-mdma/ https://rollsafe.org/how-to-take-mdma/ is an excellent resource. I've used it, had a great time, not much comedown, and would probably use it again, but I was cautious to follow all of the advice on https://rollsafe.org/how-to-take-mdma/ https://rollsafe.org/how-to-take-mdma/ If you're popping moderate or large doses every few days as if it were Adderall, you're potentially risking the chance of long-term or permanent brain damage.
- therealx 6y ago
  Many drugs are, but youre (I think), thinking of the study where they accidently used meth instead of MDMA.
cwkoss 6y ago
Note that it is spelled alpha-lipoic acid - no 'r'

bennysonething 6y ago

Genuine question, is mdma cardio toxic? Thought that was cocaine?

pvarangot 6y ago
It's not clear it's cardiotoxic even on heavy users. Most research points out that it is, but the mechanism is not well understood so it may be a correlation as most heavy users will not be leading a healthy vascular life.
- meowface 6y ago
  Importantly, it may be neurotoxic for heavy users, though. It's actually probably by far the most neurotoxic drug that's commonly used recreationally. (Believed to be due in part to the acute serotonin release, and reactive oxygen species, and risk of overheating.) This is not at all to scaremonger - just to encourage people to always research things very carefully before they consume them. https://rollsafe.org/how-to-take-mdma/ https://rollsafe.org/how-to-take-mdma/ is an excellent resource. I've used it, had a great time, not much comedown, and would probably use it again, but I was cautious to follow all of the advice on https://rollsafe.org/how-to-take-mdma/ https://rollsafe.org/how-to-take-mdma/ If you're popping moderate or large doses every few days as if it were Adderall, you're potentially risking the chance of long-term or permanent brain damage.
therealx 6y ago
Many drugs are, but youre (I think), thinking of the study where they accidently used meth instead of MDMA.

cwkoss 6y ago

Note that it is spelled alpha-lipoic acid - no 'r'