MDMA Increases Cooperation and Recruitment of Social Brain Areas When Playing Trustworthy Players in an Iterated Prisoner's Dilemma https://www.jneurosci.org/c

MDMA Increases Cooperation and Recruitment of Social Brain Areas When Playing Trustworthy Players in an Iterated Prisoner's Dilemma https://www.jneurosci.org/content/39/2/307 https://www.jneurosci.org/content/39/2/307 Abstract ran through a text optimizer: We administered 100 mg MDMA or placebo to 20 male participants in a double-blind, placebo-controlled, crossover study. Cooperation with trustworthy, but not untrustworthy, opponents was enhanced following MDMA but not placebo. Specifically, MDMA enhanced recovery from, but not the impact of, breaches in cooperation. During trial outcome, MDMA increased activation of four clusters incorporating precentral and supramarginal, gyri, superior temporal cortex, central operculum/posterior insula, and supplementary motor area. MDMA increased cooperative behavior when playing trustworthy opponents. Our findings highlight the context-specific nature of MDMA's effect on social decision-making. While breaches of trustworthy behavior have a similar impact following administration of MDMA compared with placebo, MDMA facilitates a greater recovery from these breaches of trust.